High-throughput optical microscopy is transforming the science of modern biology — from genetics to drug discovery to synthetic biology. It is rapidly improving efficiency and opening up new possibilities across a wide range of applications.
But scientists today are fundamentally constrained by the limited perspective of traditional microscopes.
As field-of-view increases, resolution decreases. Yet modern biology requires an ability to capture precise data across larger areas and at multiple points in time to understand dynamic systems and reduce costs by accelerating tedious workflows.
Microscopy also has a data problem. Image data is incredibly large, but much of what’s captured is irrelevant negative space. Parsing through the data for insights is time-consuming and expensive.
We’re on a mission to expand the field-of-view for researchers, startups, and industry while preserving resolution and streamlining automated workflows.
- Nature Photonics, March 2023
Parallelized computational 3D video microscopy of freely moving organisms at multiple gigapixels per secondThis article demonstrates how wide-field-of-view microscopy with Ramona’s multi-camera array microscope (MCAM) can resolve three-dimensional information at high speed and spatial resolution. It then shows how this technology can serve as a powerful tool for studying the behavior of freely moving organisms, such as ants, fruit flies, and zebrafish larvae.Learn more
- Elife, December 2022This paper details how Ramona’s multi-camera array microscope (MCAM) enables comprehensive high-resolution recording from multiple spatial scales simultaneously, ranging from cellular-scale structures to large-group behavioral dynamics. This allows researchers to observe the behavior and fine anatomical features of numerous freely moving model organisms on multiple spatial scales, including larval zebrafish, fruit flies, nematodes, carpenter ants, and slime mold.Learn more
- Optica, August 2021This paper details how Ramona’s multi-camera array microscope (MCAM) can quantify morphological features in bacterial colonies across multi-well plates. It shows how the system can be used to augment high-throughput assays by synchronously capturing valuable phenotypic information throughout an acquisition and analysis pipeline.Learn more
- Optica, February 2023This publication presents results from three unique MCAM configurations for different use cases. These configurations include simultaneous capture with 3D object depth estimation, continuous video capture at high resolution over a large field of view, and a high-resolution configuration to produce 9.8 GP composites of large histopathology specimens.Learn more
Roarke Horstmeyer, PhDMicroscopy
Mark Harfouche, PhDEmbedded Systems
Aurélien Bègue, PhDMicroscopy
Veton SaliuEmbedded Systems
Clay DugoSoftware Developer
Ron Appel, PhDComputer Vision
Jed DomanComputer Vision
John EfromsonComputer Vision
Kelly Pittman, PhDProduct